Sleep and Heart Health

Sleep Disordered Breathing and Central Sleep Apnea

Sleep disordered breathing disturbs a person’s normal breathing pattern during sleep and has an adverse effect on overall cardiovascular health. People with sleep disordered breathing and heart failure are at risk of ventricular arrhythmias and nocturnal sudden death.

Central Sleep Apnea (CSA) is a type of sleep disordered breathing that occurs when your brain does not send the correct signals to your diaphragm (breathing muscles). Because the diaphragm does not move appropriately, the lungs do not move air in and out in a regular rhythm. Breathing is sometimes deep and rapid and at other times slow and shallow and sometimes it stops completely before restarting again.

Central Sleep Apnea is common in patients with heart failure. CSA can lead to excessive daytime sleepiness, reduced exercise capacity, and irregular or very fast heart rhythms (arrhythmias). CSA can lead to worsening of heart failure and an increased risk of death.

The remedē® System is designed to restore natural breathing during sleep which may improve cardiovascular health…one breath at a time.


The remedē® System therapy is designed to restore a normal breathing pattern.


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  • Oldenburg O, Lamp B, Faber L, et al. Sleep-disordered breathing in patients with symptomatic heart failure: a contemporary study of prevalence in and characteristics of 700 patients. Eur J Heart Fail 2007;9:251-7.
  • Schulz R, Blau A, Borgel J, et al. Sleep apnoea in heart failure. Eur Respir J 2007;29:1201-5.
  • Javaheri S, Shukla R, Zeigler H, Wexler L. Central sleep apnea, right ventricular dysfunction, and low diastolic blood pressure are predictors of mortality in systolic heart failure. Table reprinted by permission of Elsevier. J Am Coll Cardiol 2007;49:2028-34.
  • Javaheri S, Dempsey JA. Central sleep apnea. Compr Physiol 2013;3:141–163.
  • Khayat R, Abraham WT, and Patt B.  Central Sleep Apnea is a Predictor of Cardiac Readmission in Hospitalized Patients With Systolic Heart Failure.  J Card Fail  2012; 18:534-540.

1 in 3 people with heart failure have Central Sleep Apnea and stop breathing during the night. Talk to your doctor about the remedē® System clinical study to see if you qualify.
Send us an email at or read about our clinical study at


Respicardia®, Inc.
12400 Whitewater Dr., Suite 150
Minnetonka, MN 55343 USA
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Phone: +1-952-540-4470
©2018 Respicardia®, Inc. The remedē® System has received FDA and CE Mark approvals. See Patents