SLEEP
INTERRUPTED

SLEEP
INTERRUPTED

central sleep apnea

Sleep apnea is a disorder where breathing is repeatedly interrupted while asleep. Sleep apnea is classified as either obstructive sleep apnea (OSA) or central sleep apnea (CSA).

Central sleep apnea is a form of sleep apnea that
is less common and less studied than obstructive sleep apnea. Whereas obstructive sleep apnea results from a blockage of the upper airway, central sleep apnea occurs when the brain fails to send appropriate signals to the breathing muscles to stimulate a regular breathing pattern.1

Types-of-Sleep-Apnea

Symptoms of central sleep apnea

CENTRAL SLEEP APNEA HAS SYMPTOMS THAT ARE BOTH LONG TERM AND SHORT TERM. SYMPTOMS OF CENTRAL SLEEP APNEA (CSA) INCLUDE:2-3

CENTRAL SLEEP APNEA HAS SYMPTOMS THAT ARE BOTH LONG TERM AND SHORT TERM. SYMPTOMS OF CENTRAL SLEEP APNEA (CSA) INCLUDE:2-3

slouch
Chronic fatigue
sleep at desk
Excessive daytime sleepiness
brain
Brain fog / cognitive impairment
Inability to fall asleep or get restful sleep
Many patients with CSA also have heart disease, especially heart failure.4 Within this population, patients with CSA are at increased risk for hospitalizations and even death.5,6

CENTRAL SLEEP APNEA HAS A NUMBER OF KNOWN ASSOCIATIONS:2

  • Cardiac disorders including Congestive Heart Failure (CHF) and Atrial Fibrillation (AFib)
  • High altitude
  • Opioids
  • Idiopathic central sleep apnea
  • Other medical conditions (stroke, brainstem/spinal cord disorders)

diagnosing csa

CSA is diagnosed via a home or in-lab sleep study, ethat is prescribed by a physician to determine if a patient has sleep apnea and if their primary type of apnea is central or obstructive.
house
Home Sleep Apnea Test
(HSAT, Polygram, PG)

Completed at home

Measures oxygen, air flow
and movement of the chest and
abdomen*

In-Lab Sleep Study
(Polysomnogram, PSG)

Assesses sleep stage and other sleep disorders in addition to sleep apnea

Requires overnight monitoring in a sleep lab

During the sleep study, the number of apnea and hypopnea events per hour are counted and reported as the Apnea Hypopnea Index (AHI), the most common measure of severity of sleep apnea.

START THE JOURNEY
TO BETTER HEALTH

The remedē® System is a revolutionary CSA treatment that improves sleep, enhances well-being, and reduces daytime sleepiness, enabling better overall health.7

Could remedē® be right for you?

Answer a few short questions to see if you may be a candidate.

*Required to distinguish the type of sleep apnea.

  1. Costanzo M.R., Khayat R., Ponikowski P., et al. Mechanisms and clinical consequences of untreated central sleep apnea in heart failure. J Am Coll Cardiol. 2015; 65:72–84.
  2. Javaheri S., Dempsey J.A. (2013) Central sleep apnea. Compr Physiol 3:141–163.
  3. Dempsey JA. Crossing the apnoeic threshold: causes and consequences. Exp Physiol 90: 13–24, 2005.
  4. Bekfani T, Abraham WT. Europace. 2016 Aug;18(8):1123-34. doi: 10.1093/europace/euv435. Epub 2016 May 26.
  5. Khayat R et al. Central sleep apnea is a predictor of cardiac readmission in hospitalized patients with systolic heart failure. J Card Fail 2012;18:534–40.
  6. Khayat, R et al. Sleep disordered breathing and post-discharge mortality in patients with acute heart failure, European Heart Journal 2015;36 1463–1469.
  7. Costanzo M, et al. Transvenous neurostimulation for central sleep apnoea: a randomised controlled trial. The Lancet. 2016; 388: 974–82.
  1. Javaheri S, Dempsey JA. Central sleep apnea. Compr Physiol 3:141-163; 2013; Costanzo JACC.
  2. Costanzo MR, Khayat R, Ponikowski P, et al. State-of-the-art review: Mechanisms and clinical consequences of untreated central sleep apnea in heart failure. J Am Coll Cardiol 2015;65:72-84.
  3. Bekfani T and Abraham WT. Current and future developments in the field of central sleep apnea. Europace, 2016;18:1123-1134.
  4. Costanzo M, et al. Transvenous neurostimulation for central sleep apnoea: a randomised controlled trial. The Lancet. 2016; 388: 974–82.
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For Patients

IMPORTANT SAFETY INFORMATION

The remedē® System is indicated for moderate to severe Central Sleep Apnea in adult patients.

Your doctor will need to evaluate your condition to determine if the remedē system is right for you. You will not be able to have an MRI or diathermy (special heat therapies) if you have the remedē system implanted. The remedē system may be used if you have another stimulation device such as a heart pacemaker or defibrillator; special testing will be needed to ensure the devices are not interacting.

As with any surgically implanted device, there are risks related to the surgical procedure itself which may include, but are not limited to, pain, swelling, and infection.

Once the therapy is turned on, some patients may experience discomfort from stimulation and/or from the presence of the device. The majority of these events are resolved either on their own or by adjusting the therapy settings. The remedē system may not work for everyone. There are additional risks associated with removing your system. If you and your doctor decide to remove the system, another surgery will be required.

Be sure to talk with your doctor so that you thoroughly understand all of the risks and benefits associated with the implantation of the remedē system. Rx only. For further information, please call +1-952-540-4470 or email info@respicardia.com.