Sleep apnea is a serious condition in which a person stops breathing during sleep.

CSA Risk Factors
Certain factors put you at increased risk of CSA:1

Heart Disorders:
People with heart failure or heart rhythm disorders such as atrial fibrillation

Brain Conditions:
Certain brain conditions such as stroke or tumor can impair the brain’s ability to regulate breathing

Males are more likely to develop CSA than females

Over 65 years of age

CSA Symptoms2

Breathing that temporarily stops while asleep

Shortness of breath at night

Difficulty concentrating

Nighttime urination

Daytime fatigue

Decreased stamina

Healthy vs. Disrupted Breathing

During healthy sleep, the brain controls breathing by sending the proper signals to the muscles that control breathing. For adults with CSA, the brain fails to send appropriate signals to these muscles.

CSA and Heart Health

CSA is common in cardiac patients, primarily patients with heart failure. CSA causes a repeating cycle of disruptive breathing, nighttime wakefulness and increased activation of the body’s sympathetic nervous system (“fight or flight response”) that contribute to heart failure.2

Studies have shown that patients with CSA are at risk for heart rhythm disturbances, high blood pressure, and worsening heart failure.3 Speak with your physician today to learn about your risks.

Diagnosing CSA

CSA frequently occurs among people who also have other diseases such as chronic heart failure, atrial fibrillation, stroke and may be seen in patients with chronic kidney disease and diabetes.2 As a result, symptoms can be subtle and often overlap.

To diagnose CSA, a physician will prescribe a home or in-lab sleep study to determine whether the sleep disturbance results from inappropriate signals from the brain (CSA) or an airway blockage (OSA).



The remedē® System is a revolutionary CSA treatment that improves sleep, enhances well-being, and reduces daytime sleepiness, enabling better overall health.4

NEXT: The remedē System

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  1. Javaheri S, Dempsey JA. Central sleep apnea. Compr Physiol 3:141-163; 2013; Costanzo JACC.
  2. Costanzo MR, Khayat R, Ponikowski P, et al. State-of-the-art review: Mechanisms and clinical consequences of untreated central sleep apnea in heart failure. J Am Coll Cardiol 2015;65:72-84.
  3. Bekfani T and Abraham WT. Current and future developments in the field of central sleep apnea. Europace, 2016;18:1123-1134.
  4. Costanzo M, et al. Transvenous neurostimulation for central sleep apnoea: a randomised controlled trial. The Lancet. 2016; 388: 974–82.
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For Patients


The remedē® System is indicated for moderate to severe Central Sleep Apnea in adult patients.

Your doctor will need to evaluate your condition to determine if the remedē system is right for you. You will not be able to have an MRI or diathermy (special heat therapies) if you have the remedē system implanted. The remedē system may be used if you have another stimulation device such as a heart pacemaker or defibrillator; special testing will be needed to ensure the devices are not interacting.

As with any surgically implanted device, there are risks related to the surgical procedure itself which may include, but are not limited to, pain, swelling, and infection.

Once the therapy is turned on, some patients may experience discomfort from stimulation and/or from the presence of the device. The majority of these events are resolved either on their own or by adjusting the therapy settings. The remedē system may not work for everyone. There are additional risks associated with removing your system. If you and your doctor decide to remove the system, another surgery will be required.

Be sure to talk with your doctor so that you thoroughly understand all of the risks and benefits associated with the implantation of the remedē system. Rx only. For further information, please call +1-952-540-4470 or email